http://forums.toshiba.com/t5/Keyboards-Touchpads-Knowledge/How-do-I-change-my-touchpad-settings-and-features-on-Window-8/ta-p/426593
please watch video
i have a toshiba satellite E45t-B4300. Had the same problem with the touch pad not working.only worked when i use a mouse. on your keypad..there's F1-F10 button, to unlock the touchpad, mines was F5. hope this helps.