I have Xpadder for my computer so that I can program controls for my Xbox 360 controller to add support for games that don't have it.
Now before you start back with K/M is superior I just want to explain how the software works... And how you can use the software to prank people.
Xpadder doesn't add support to the game, it emulates the K/M. This means that I can set my wireless 360 controller, which has a range of 30 feet, to function as the mouse. I can also program any function I want, from CTRL+ALT+Delete to ALT+TAB and anything else out there, so that I can really screw with people's heads.
I did this a while back actually. I was helping a buddy of mine do a school project by making a video. Xpadder was already running and I just turned on my controller. I subtly moved the right thumbstick, default mouse emulation, and racked in the laughs as my friend shook the mouse, then lifted the mouse, then shook it again in frustration.
Good times.