If you're using headphones, then set it up as stereo. What do you have for audio? Onboard or discreet. Using my SB Zx with both headphones and 5.1, I have it set up in two profiles, one for each. If I switch the card to the headphones with the 5.1 profile, there's a weirdness to it. it doesn't sound good. I'm not an audiophile per se, just someone who likes good sound. Always use the correct number of channels for the speaker/phones setup.