what your asking requires either a usb mixer with a seperate dac ( i use an mg10xu with a sound blaster x-fi sound card for movies and what not while gaming so i have control ), a dac for everything non skype and the usb mixer for skype , and you can do exactly that , left channel skype , right channel music ect , otherwise , i dont think it is possible to seperate audio to individual channels on one audio device ( onboard audio for example)