It's possible but it depends what you mean by serious and how much the eye candy matters to you. A 1050ti will run most games at up to 1920 x 1080 resolutions at medium or high settings and manage good framerates. But on more demanding titles you may have to compromise on visual quality a bit.
Another issue with laptops is the CPU, many are only dual cores with hyper threading despite an i5 or i7 name so are more like a desktop i3. A genuine Quad core with decent clock speeds can really help in some games.
There's always a trade off or compromise to be made. Desktops are more flexible and upgrade-able and cost less for better gaming performance. On the other hand laptops are portable and come all set up and ready to go. By the time you add a keyboard, mouse, and screen for decent gaming experience you might as well be using a desktop. Gaming on a laptop keyboard and screen is something I'd only do when travelling, it's really not the same.
Don't let me put you off though, you can certainly enjoy gaming on a laptop if you choose carefully. I'm just biased as a long time desktop gamer.