Program not responding

Hello, is there any way to fix laptop randomly freeze? its been 2 years i experienced this things i tried: disabling windows index disabling superfect/sysmain disk cleanup delete %temp% files msconfig max cores changing power plan to high performance update drivers etc, and none of them worked...

I'm curious, when an app stops responding, I understand it means what it says but what does it mean in more detail? And does the computer do something (if so, what?) to rectify this issue when you 'wait for the program to respond' or does it do nothing?