actually if you want to get technical.... you "can" use multiple smaller sound systems to re-create surround sound.
if the systems take 3.5mm as an input and you use something like a hdmi to 5.1 extractor with hdmi passthrough to pass video along via hdmi but pull off the different channels in single rca plugs you could run anything from a 5.1 to 6.3. now, you wont get anything which sounds exactly like 5.1 and a 5.1 set is likely going to be quite a bit cheaper and also sound better as well which makes this highly impractical unless you just happened to have lots of stuff laying around you got for free.
can you get surround sound out of 2.0/2.1 speakers? no, but you can get virtual surround sound (simulated) if you ran something...