Everyone's ecosystem is slightly different. I found the results of removing Chrome extremely effective in the performance of my 8 year old iMac with 8GB of memory and plenty of spare disk space. My wife's iMac (not as old) does not have the same latency issues, yet despite all the clean-up and minimization, the performance was horrendous, bordering on unusable. Thanks to this, I have a much better response to startup, browser searches and overall usability of the iMac.
There is really nothing to lose in trying this. I exported/imported my passwords and bookmarks from Chrome to Safari. If this did not work, I would simply reinstall a fresh release. At this point, I am fine not going back to Chrome.