Yes, you can by using either the analog or S/PDIF connector. And run the sub through the Logitech audio controller and NOT your surround receiver else you may damage the subwoofer. But, I have to ask...why would you want to to this? The Logitech Z-5500 speakers are designed specifically for use as computer speakers. Using them as your main entertainment system is okay, but lack the overall punch of real surround speakers. Just saying...