You didn't mention the system that will be driving all of your speakers. The GOOD NEWS is that most all decent A/V receivers have ways to match speakers, using EQ, timing delay (depends on distance to listeners) and volume level adjustments. Some receivers use a test signal (pink noise) and a microphone and automatically EQ for "flat" response. No need to toss those Infinitys!
If you've gone total high-end with monoblocks for the mains, for example and a nice high-end DSP (ATMOS) and pre-amp, with dedicated high-current multi-channel amp for the surrounds (center, sides, rear and possibly ceiling), you have more flexibility and certainly better performance. My system has been fully calibrated for the room (20*25), with full acoustic wall treatments to avoid time-smearing reflections.
In order to properly integrate a sub into the environment, you need to know the low-end roll-off of your mains. Let's say you're at -3dB@30Hz. Your sub will need to "cross in" near that frequency or higher (choose "high-pass" point for mains, low-pass for sub), in order to not be too "heavy" at the bottom end of the spectrum. Most subs have built-in crossovers for this. Many A/V receivers and DSP pre-amps will be able to as well, in the speaker set-up section of the settings menu.
Being a high-end person, you most likely know this - One thing the A/V components cannot do is compensate for phase. Many subs have continuously-variable phase controls and some simply have 90 or 180 or both. Phase is CRITICAL in the performance of speakers, especially in the lower frequencies and out-of-phase mains or surrounds will TOTALLY destroy imaging. The alternative to those controls on the sub is to rotate the sub. This is experimental and depends on the configuration of your sub - which way the driver(s) is/ are facing has everything to do with acheiving the proper phase angles to reinforce the lowest octaves. Also, positioning the sub or subs in various spots in the room can have a positive or negative effect. Now, we're talking room modes, length of sound waves (40 feet @ 20Hz!!), cancellations, etc.... Integrating speakers into a room properly and knowing their response curves, room modes, timings, reflections, etc... can be a very complicated task, but the reward is awesome.