My laptop came with Vipre Security. Have had this for many years now and it's always worked fine. Have never tried to call the tech support but I do believe they provide a 24/7 number. However they also have and, in my experience, always respond to emails. (My laptop was secondhand so the only time I've ever needed to contact them was to renew subscription...)
The program updates every time I'm online but doesn't slow the computer down while doing so. It does warn, block, redirect if it encounters a problem and it also can do scans and removals of problems, even on USB devices.
You have to pay for Vipre but they sometimes have sales, too. And often it's possible to renew subscription for multiple years at discount. So average price per year can end up being $25 or less.
My laptop is covered till 2016. Kind of sad, really. The laptop itself may not last that long. So will get to learn if the program can be transferred, probably soon.
NOTE: Do also use CCleaner by Piriform and a very old version of WinASO to clear cache files. Both were free, work okay and seem to help reduce scan times for Vipre.