That's a very large spot!!
If it is always present regardless of program used, then it might a hardware issue with the display or maybe the video card (if discrete card installed)? A remote possibility is that some malware may be displaying this "image".
If the "spot" only appears sometimes, it could still be an intermittent hardware issue, but it may be malware?
If there is a discrete video card, try another video card, and/or try the original video card in another computer.
Run on-demand scan for malware using several programs (one at a time). Several programs because one program is unlikely to find all known malware. Programs such as Malwarebytes Anti-Malware and Emsisoft Anti-Malware.