It might be trying to share PCIe lanes & causing a conflict with the 650m, pulling too much power (more than the AC adapter can supply), etc. You mentioned a Beast enclosure, but which model, specifically?
Exp GDC ,I have disabled old graphics card disabled integrated nic ,Dow loaded driver for 1060 what am I missing if someone can help me to get this right I will do what ever I can to make it worth while
Sounds like it's not compatible. Could be firmware, probably even power requirements (1060 draws around 120 watts and up, 650m draws only 45 watts - your battery and AC adapter likely can't supply enough power).