Yeah just do a remapping of your keys.
If you want to screw with someone, may I suggest getting a wireless USB keyboard, plugging the dongle into their computer, and typing while they are using the computer ;D We did that a lot for new people in my research lab. Lots of fun.
Also, if you know how, use the cron scheduler (for Windows or Linux) and have it open the CD drive every XX minutes. Thats pretty funny too XD