Well some options don't actually work in "Safe Mode", so the speakers on yours may be one. However that shouldn't cause the dying.
I would still try running scans for viruses, malware, etc., outside "Safe Mode" to be sure. Also, check the device to see if there are any restore points you can go back to, that may be prior to the problem starting. Or if you know of any updates or program installations that came just before this happened, I would look at them as well. Perhaps uninstall and see if it is resolved.