It's almost certainly the fan that cools the processor and dust the unbalancing the blades. A PC store will sell you a can of compressed air, aim that through the vent and spray a little while the machine is running. Don't overdo it - less is more in this case.
Hopefully the dust will shift and the noise will cease but if it doesn't, it may be a fan bearing that's worn out and that would mean replacing the cooling system or at least, just the fan.