Malware is blocking Anti-Virus and is making Temp folder Read-Only?

[InfiniteAttack]

I believe malware as an .iso acted like a disc and used "AutoPlay" to run itself. Windows Defender and Malwarebytes scans will not start and my Temp folder is locked to read-only so no programs will install.

 

[Darkseiders]

Have you tried malwarebytes chameleon?