I noticed that Windows 10 has an anti-malware service running already, so it would not have a hit on your CPU. Malwarebytes blocked a bunch of malicious websites for me. So far so good. Don't install hacked software and it will probably work sufficiently.
I have Windows Defender and Malwarebytes running together on Windows 10 with no problems at all.
I also have (Must be without real time protection) Adaware a very light programme and so long as Adaware real time protection is shut of, I have no problems - I even have the pop up blocket which works with Chrome.