Remove all Unwanted programs from your PC that are responsible for the pop-up ads.
Scan your system with the help of adware removal tool like Adw cleaner or spy hunter.
Disable all unwanted add ons from your Browser and reset your browser settings by selecting setting option in your chrome menu.
Remove all suspicious start-up items from your system.
Download a strong antivirus program like Avira, Immunet, AVG or Panda in your PC and scan your whole system.