Focusrite 2i4 and GTA V not compatable?

Aug 27, 2014
I have my 2i4 set at 2 channel, 16 bit, 44.1khz running to my studio monitors. They work perfectly when listening to itunes or watching youtube videos, but when I open up GTA V the sound gets really messed up on the monitors and on my headphones.
I have not tried it with other games yet.
Please help me this is really weird