It's only Skype, and I turned off global hotkeys and it's still doing that. I don't know where to find out why the Alt key alone is causing the huge volume decrease. The Alt key usually requires another key to be a hotkey, but this is when only the Alt key is held down. As soon as the Alt key is released, the volume increases to normal. Any ideas?Sounds like that key may be set to mute or volume drop in the program or some hotkey setup.