Some of that stuff can be a REAL pain to get rid of, plenty of people I know just gave up, formatted their drives and reinstalled everything from scratch, it's a brutal way of doing it but very effective.
Quite a lot of this crud lives in your Temp folders, an easy way to clear them out is to use something like Ccleaner to clear them out then use the Windows disc cleaner tool to finally erase any surviving temporary files.
Once that is done run full virus and malware scans to clear out the remaining garbage.
A few tips to keep yourself infection free:
Never open an unknown E-mail, no matter who it says it's from, no matter how legit it seems, if you don't know the sender or aren't expecting a communication from them either junk it or contact them directly, by phone.
Never click on any window or box that opens unless YOU have commanded it to appear/open, we've all seen those little boxes that pop up telling us our system is riddled with nasties or our drivers are outdated, if one of those appears: CTRL+ALT+DEL to Task Manager, close down your browser from there, then run Ccleaner to get rid of the cookies that will redirect you to the same place.
If you download anything, photos, software, music, ANTHING, scan it with your AV software before you open it or unzip it, even trusted sites get hacked.
Stay away from Torrent sites and those tempting...Artistic places that are keen to show you the naked female (or male) form in all its various glories.
Create another user profile with limited authority, a lot of nasties need Administrator privileges to install or run, do your browsing with this profile to keep them at bay.