The best anti-virus and anti-malware is you not clicking/going where you shouldn't. After that, I like what's light, non-invasive and relatively cheap. I use webroot secureanywhere this year(meh) along with MalwarebytesPRO, Spybot free, SpywareBlaster and Hitman Pro as a back-up cleaner.
I forgot about BitDefender..lol
Whatever you so, don't get PCMatic... I hear it's awful.
Of course I understand that you shouldn't go to certain sites or open certain emails, but I just feel better with a safety net. If I'm running an SSD and an HDD my OS is on my SSD, that's where I would download the drivers right? What about anti-virus software? SSD or HDD?