I've built computers and I can fix most problems but I have never seen this before. It happens every time I attempt to shut down and prevents me from shutting the laptop down. It's brand new. Please see included picture http/imgur.com/F59IwvL
Please try disabling all your startup items first specially ASUS related softwares. If this doesn't do the trick a Factory Reset might be required. According to some other forums that error that you're getting is caused by a corrupted ASUS software you might also want to consider running sfc/scannow as well in Command Prompt before doing a Factory Reset.