Go to your desktop and add a Chrome shortcut to it. Right-click the shortcut and select properties. Modify it to show as below
"C:\Program Files (x86)\Google\Chrome\Application\chrome.exe" --profile-directory=Default --force-wave-audio --try-supported-channel-layouts --disable-audio-resampler"
It has worked for me on Windows 10 x64, Chrome Version 65.0.3325.181 (Official Build) (64-bit)
Sound Settings/Details - Realtek HD Audio, 5.1 Audio, 24-bit 48000Hz