"Windows Defender" and "Avira" are quite different. Both do a good job, but neither covers everything. I have both plus "Spybot" and "Ad-Aware". And I run them all regularly.
With our computers connected to the net all the time, and so much is accessed that is downloaded to your device, it is way better to be safe and run extra stuff than it is to run less and risk issues. All it takes is one little thing to sneak through and wreak havoc on your system.
While I know "Avira" can be really annoying when it automatically starts doing things and using the resources while you are in the middle of something. That is my major pet peeve about the program, that you can't turn that aspect off and choose when all stuff is done, it is still better to have it. Or you can try a different software that does the same thing.