Question can't get my Klipsch R-12SW to work on my MSI Z390-A Pro

Your AVR has a discrete multichannel analog input? You did set up the receiver?
The orange audio output has both the center and sub outputs. You can't really tell which is which so connect one to the center input. If you hear dialogue then it's correct.
Check that your audio control panel is set for 5.1.
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