Honestly I think they SHOULD ignore the story from the games. Going through multiple media outlets should not be a way to tell the same story, but rather, expand upon the universe as a whole.
I'd find it more interesting if it wasn't about Shepard. Also, it becomes more convoluted seeing as Shepard in the game was a customizable figure, despite the default look. And then, when you HAVE a default look, for any character, and voices, you run into the trouble where fans are unsettled because that's not what they saw in the game.
So instead, in my opinion, they'd have better luck working together with the writers of the game to tell a new story somewhere else in the universe, maybe a different time as well.
That's just me though.