I have the same problem with the keyboard and the mouse on the Acer Aspire 5100 Notebook computer. I CANNOT EXPLORE or go thru ANY BIOS OPTIONS or "explore" anything else BECAUSE THE KEYBOARD IS DEAD! NO RESPONSE! NO MOUSE PROINTER MOVEMENT! No USB function. No nothing. The computer boots just fine. Everything works EXCEPT the keyboard and the mouse. I can't do a doggone thing. However, I am using the Acer Aspire 5100 Notebook computer rite now. I'm typing this on it. How? I went out and bought a 2-Port USB card bus adapter, also known as a PCMCIA USB adapter. I plugged my USB keyboard and mouse into the PCMCIA USB ports and I'm able to use my laptop this way. Of course, this works only when Windows loads. I still can't access the bios via pressing F2. I am tempted to update the bios via bios update software but something tells me to leave well enough alone and use my computer as I am using it now.