My Toshiba satellite keyboard or mouse pad won't respond boot on

Try attaching an external keyboard and mouse while the laptop is off, and then turn it on. If they work fine, then there may be a problem with the attached keyboard and touchpad. However, before replacing them I would try the following. If it works, great. If not, then I would replace the parts. Either that or keep using the external ones.

1. Uninstall the keyboard driver.
2. Reboot the computer (without reinstalling the driver).
3. When it restarts, it should reinstall the driver on its own.

also...

1. Go into "Control Panel".
2. Click "Hardware and Sound".
3. Now click "Mouse and Touchpad".
4. Now go to "Additional mouse options".
5. The Mouse Properties window will open. In here click on your device.
6. Make sure your device is set to enabled. If it isn't then click "Enable Device".
7. Exit both that screen and "Control Panel".

Also, you might want to check for updates to your drivers, including the Synaptics drivers.